It should have been a pleasant and above all an absolutely normal trip to London, but with Martin Mystère involved nothing can ever be simple and uncomplicated. While visiting an acquaintance, Martin, Java and Diana discover quite by chance that every man, woman and child of the earth seems to have disappeared. Are our three friends perhaps the last remaining persons on earth?
Mystery comes to London just in time to greet his friend Dylan Dog, before they disappear into thin air!